Eidi, M., Pouyan, O., Shahmohammadi, P., Saeidi, H., Bahar, M., and Eidi, A. L-acetylcarnitine as a new therapeutic approach for peripheral neuropathies with pain. Anti-ischaemic efficacy of L-propionylcarnitine - a promising novel metabolic approach to ischaemia? Dal Negro R, Pomari G, Zoccatelli O, and et al. View abstract. View abstract. Sugino, T., Aoyagi, S., Shirai, T., Kajimoto, Y., and Kajimoto, O. Cruciani RA, Zhang JJ, Manola J, Cella D, Ansari B, Fisch MJ. Reuter, S. E. and Evans, A. M. Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Schoderbeck M, Auer B, Legenstein E, et al. Shakeri, A., Tabibi, H., and Hedayati, M. Effects of L-carnitine supplement on serum inflammatory cytokines, C-reactive protein, lipoprotein (a), and oxidative stress in hemodialysis patients with Lp (a) hyperlipoproteinemia. Pediatrics 2002;109(4):622-626. Riccioni, C., Sarcinella, R., Izzo, A., Palermo, G., Liguori, M., Caliumi, C., Carloni, E., Paolucci, A. M., D'andrea, P., and Pompili, S. Rehabilitative treatment in peripheral artery disease: protocol application and follow-up. Int J Clin Pharmacol Ther Toxicol 1985;23:569-72. Mondillo, S., Faglia, S., D'Aprile, N., Mangiacotti, L., Campolo, M. A., Agricola, E., and Palazzuoli, V. [Therapy of arrhythmia induced by myocardial ischemia. Neri S, Pistone G, Saraceno B, et al. Ann Neurol 1988;24:301. Vasc.Med 2012;17(3):145-154. Biochem Pharmacol 1995;49:1403-10. View abstract. 2010;16(5):420-422. 2006;27(6):599-604. View abstract. Cao, Y., Wang, Y. X., Liu, C. J., Wang, L. X., Han, Z. W., and Wang, C. B. Clinical Trials Journal 1986;23(6):338-344. The effects of L-carnitine on human stamina. View abstract. Anti-human immunodeficiency virus (HIV) activitiy, safety, and pharmacokinetics of adefovir dipivoxyl (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-infected patients. Evaluation of the efficacy of propionyl-L-carnitine versus pulsed muscular compressions in diabetic and non-diabetic patients affected by obliterating arteriopathy Leriche stage II. Nootropics are drugs or supplements that can boost brain function. Valcour, V., Yeh, T. M., Bartt, R., Clifford, D., Gerschenson, M., Evans, S. R., Cohen, B. Bjornsson, E. Hepatotoxicity associated with antiepileptic drugs. Am.J Clin Nutr. Yderstraede, K. B., Pedersen, F. B., Dragsholt, C., Trostmann, A., Laier, E., and Larsen, H. F. The effect of L-carnitine on lipid metabolism in patients on chronic haemodialysis. The effects of magnesium, L-carnitine, and concurrent magnesium-L-carnitine supplementation in migraine prophylaxis. Brevetti G, Chiariello M, Policicchio A, and et al. J Pharmacol Exp Ther 1999;290:1482-92. Prevention of hepatotoxicity recurrence with valproate monotherapy and carnitine. Sigman, M., Glass, S., Campagnone, J., and Pryor, J. L. Carnitine for the treatment of idiopathic asthenospermia: a randomized, double-blind, placebo-controlled trial. Hepatol. View abstract. Holme E, Greter J, Jacobson CE, et al. Gwak, J. H., Lee, J. H., Lee, S. J., Park, H. W., Kim, Y., and Hyun, Y. J. 2007;45(12):932-936. J Inherit.Metab Dis 2008;31(4):503-507. View abstract. The study in the European Heart Journal involved 113 healthy men and women to determine the effect of consuming red meat and white meat . [The impact of L-carnitine administration on the serum level of myocardium injury markers in patients with acute carbon monoxide poisoning]. Yet, there are a few known side effects that include agitation, insomnia and nausea. View abstract. Wang DD, Wang TY, Yang Y, He SM, Wang YM. Rathod, R., Baig, M. S., Khandelwal, P. N., Kulkarni, S. G., Gade, P. R., and Siddiqui, S. Results of a single blind, randomized, placebo-controlled clinical trial to study the effect of intravenous L-carnitine supplementation on health-related quality of life in Indian patients on maintenance hemodialysis. Zhang, X. L. and Ge, H. Clinical observations on treating ischemic cardiomyopathy using Fasudil and L-carnitine. J Pharm Sci 1995;84(5):627-633. Clin Exp.Rheumatol. Brevetti, G., Attisano, T., Perna, S., Rossini, A., Policicchio, A., and Corsi, M. Effect of L-carnitine on the reactive hyperemia in patients affected by peripheral vascular disease: a double-blind, crossover study. Arch.Pediatr. It is used for weight loss and may have an impact on brain function. Carnitine, valproate, and toxicity. View abstract. Mingrone G. Carnitine in type 2 diabetes. Reversal of haemodialysis induced hypertriacylglycerolemia by L-carnitine. Hum.Reprod. J.Altern.Complement Med. Shojaei, M., Djalali, M., Khatami, M., Siassi, F., and Eshraghian, M. Effects of carnitine and coenzyme Q10 on lipid profile and serum levels of lipoprotein(a) in maintenance hemodialysis patients on statin therapy. Iran J Kidney Dis 2011;5(2):114-118. View abstract. B., Lagler, F., Maier, E. M., Schwahn, B., Tokatli, A., Dursun, A., Coskun, T., Chalmers, R. A., Koeller, D. M., Zschocke, J., Christensen, E., Burgard, P., and Hoffmann, G. F. Natural history, outcome, and treatment efficacy in children and adults with glutaryl-CoA dehydrogenase deficiency. Cardiologia 1990;35(7):591-596. Intern.Med 2010;49(16):1717-1725. Seems to help my energy and especially notice that my gums seem healthier while taking it. Am.J Kidney Dis 1999;34(4):678-687. J Clin Hypertens.(Greenwich.) How Much Caffeine Is Okay? The Effects of L-Carnitine, Acetyl-L-Carnitine, and Propionyl-L-Carnitine on Body Mass in Type 2 Diabetes Mellitus Patients. Lipids Health Dis. Lagioia, R., Scrutinio, D., Mangini, S. G., Ricci, A., Mastropasqua, F., Valentini, G., Ramunni, G., Totaro, Fila G., and Rizzon, P. Propionil-L-carnitine: a new compound in the metabolic approach to the treatment of effort angina. Optom.Vis.Sci 2011;88(12):1439-1444. Jeulin C, Soufir JC, Marson J, et al. Italian Study Group on Carnitine and Male Infertility. View abstract. Bazzato, G., Mezzina, C., Ciman, M., and Guarnieri, G. Myasthenia-like syndrome associated with carnitine in patients on long- term haemodialysis. Baghban F, Hosseinzadeh M, Mozaffari-Khosravi H, Dehghan A, Fallahzadeh H. The effect of L-Carnitine supplementation on clinical symptoms, C-reactive protein and malondialdehyde in obese women with knee osteoarthritis: a double blind randomized controlled trial. Oral L-carnitine supplementation in low-birth-weight newborns: a study on neonates requiring combined parenteral and enteral nutrition. View abstract. While l-carnitine itself has been shown to favorably affect recovery in trained athletes, the studies are generally weak, lacking a large enough sample size, a strong control group, and conclusive results. Treatment with acetyl L-carnitine also appeared to protect these mice, suggesting that a similar preventative approach might work for depression-prone people. View abstract. Nephron 1984;38(2):120-124. Int J Sports Med 1989;10(3):169-174. 2011;22(6):1155-1159. Melegh, B., Kerner, J., Sandor, A., Vinceller, M., and Kispal, G. Effects of oral L-carnitine supplementation in low-birth-weight premature infants maintained on human milk. Am J Dis Child 1991;145:999-1001. 2008;15(8):595-601. A. Pediatr.Res. Caruso U, Leone L Cravotto E Nava D. Effects of L-carnitine on anemia in aged hemodialysis patients treated with recombinant human erythropoietin: A pilot study. View abstract. The process is the ability to heal the body, which is a daily process. Pharmacol Rev 2002;54:589-98. Australas Psychiatry. Fujiwara, M., Nakano, T., Tamoto, S., Yamada, Y., Fukai, M., Takada, K., Ashida, H., Shimada, T., Ishihara, T., and Seki, I. Vascular Surgery 1991;25(8):607-617. Jacoba KG, Abarquez RF, Topacio GO, and et al. Winter SC, Szabo-Aczel S, Curry CJR, et al. L-Carnitine may cause serious side effects. Interestingly, food sources of L-carnitine have a greater absorption rate than supplements. View abstract. View abstract. The effect of L-carnitine supplement on dialysis patients [abstract]. View abstract. 1992;140(4):353-377. Dokmeci, D., Inan, M., Basaran, U. N., Yalcin, O., Aydogdu, N., Turan, F. N., and Uz, Y. H. Protective effect of L-carnitine on testicular ischaemia-reperfusion injury in rats. G.Ital.Cardiol. Jung, J., Eo, E., and Ahn, K. O. Effects of L-propionylcarnitine on ischemia-induced myocardial dysfunction in men with angina pectoris. Derosa, G., Cicero, A. F., Gaddi, A., Mugellini, A., Ciccarelli, L., and Fogari, R. The effect of L-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus. Mol.Genet.Metab 2008;94(3):287-291. 2010;106(4):296-301. View abstract. View abstract. Barditch-Crovo P, Toole J, Hendrix CW, et al. A., Servan-Schreiber, D., Panchalingam, K., and McClure, R. J. View abstract. View abstract. Jpn Heart J 1995;36(3):319-331. EXCLI J 2019;18:631-43. doi: 10.17179/excli2019-1447. Spagnoli A, Lucca U, Menasce G, et al. The antagonistic effect of carnitine in hyperthyroidism. View abstract. Scaglia F, Longo N. Primary and secondary alterations of neonatal carnitine metabolism. Bradycardia treatment depends on the underlying cause of the low resting heart rate but may also include the surgical placement of a pacemaker. Malaguarnera, M., Vacante, M., Giordano, M., Motta, M., Bertino, G., Pennisi, M., Neri, S., Malaguarnera, M., Li, Volti G., and Galvano, F. L-carnitine supplementation improves hematological pattern in patients affected by HCV treated with Peg interferon-alpha 2b plus ribavirin. View abstract. Clin Trials J 1990;27:155-163. Examples: atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal), sotalol (Betapace), timolol (Timoptic) and some other drugs whose chemical names end with "-olol." How they can cause insomnia: Beta-blockers have long been associated with sleep disturbances, including awakenings at night and nightmares. 2010;44(7-8):1287-1293. "Product Information. Cochrane.Database.Syst.Rev. View abstract. Can carnitine cause insomnia? View abstract. 1987;1(4):238-241. View abstract. A double-blinded, crossover study. A., Izquierdo, M. A., Jimeno, J., and Raymond, E. Reports of clinical benefit of plitidepsin (Aplidine), a new marine-derived anticancer agent, in patients with advanced medullary thyroid carcinoma. Am.J Clin Oncol. Pettegrew JW, Klunk WE, Panchalingam K, et al. Nephron Clin.Pract. View abstract. Dutta, A., Ray, K., Singh, V. K., Vats, P., Singh, S. N., and Singh, S. B. L-carnitine supplementation attenuates intermittent hypoxia-induced oxidative stress and delays muscle fatigue in rats. However, on account of strict homeostatic regulation of plasma L-carnitine concentrations, higher doses of L-carnitine supplementation may not provide additional therapeutic benefits. 2008;118(5):281-290. Int J Tissue React. 2014 Oct;84(4):821-5. Diabetologia 1995;38(1):123. Plochl, E., Sperl, W., Wermuth, B., and Colombo, J. P. [Carnitine deficiency and carnitine therapy in a patient with Rett syndrome]. Cell Biochem.Funct. View abstract. A., and Barrington, K. J. Horm.Metab Res. Clin Physiol 1984;4(4):363-365. Gynecol Endocrinol 2021;1-5. [Infantile encephalopathy associated with the MELAS A3243G mutation. Clin Trials J 1988;25:227-237. As a supplement, acetyl-L-carnitine is usually considered safe when taken as directed. Prog Retin Eye Res. The effect of L-carnitine and isoflavone supplementation on weight reduction and visceral fat accumulation in overweight women. B., Gokcay, G., Grunewald, S., Guffon, N., Maier, E. M., Morava, E., Geb, S., Schwahn, B., Walter, J. H., Wendel, U., Wijburg, F. A., Muller, E., Kolker, S., and Horster, F. Diagnostic work-up and management of patients with isolated methylmalonic acidurias in European metabolic centres. Gonzalez-Ortiz, M., Hernandez-Gonzalez, S. O., Hernandez-Salazar, E., and Martinez-Abundis, E. Effect of oral L-carnitine administration on insulin sensitivity and lipid profile in type 2 diabetes mellitus patients. View abstract. View abstract. 2011;(6):CD003917. 2006;115(1-2):91-96. 2014 Jul 21;14:88. Interactions doi: 10.1002/14651858.CD011265.pub2. J Clin Oncol. Don't use CoQ10 if you're pregnant or breast-feeding without your doctor's approval. Trovato GM, Ginardi V, Di Marco V, and et al. View abstract. J Mol.Histol. Clin Nutr ESPEN. Foitzik, K., Hoting, E., Heinrich, U., Tronnier, H., and Paus, R. Indications that topical L-carnitin-L-tartrate promotes human hair growth in vivo. J Huazhong.Univ Sci Technolog.Med.Sci 2006;26(2):188-191. View abstract. By Steve Blechman BREAKING NEWS! View abstract. Prolonged moderate-intensity exercise without and with L-carnitine supplementation in patients with MCAD deficiency. Immunopharmacol.Immunotoxicol. View abstract. Taking too much (2 to 3 grams . Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. A long-term, randomised, double-blind, placebo-controlled study. Pastoris, O., Dossena, M., Foppa, P., Catapano, M., Arbustini, E., Bellini, O., Dal Bello, B., Minzioni, G., Ceriana, P., and Barzaghi, N. Effect of L-carnitine on myocardial metabolism: results of a balanced, placebo-controlled, double-blind study in patients undergoing open heart surgery. Efficacy and safety of entecavir plus carnitine complex (GODEX) compared to entecavir monotherapy in patient with ALT elevated chronic hepatitis B: J.Mazandaran Univ.Med.Sci. View abstract. 2009;48(5):587-596. 2007;25(2):182-188. View abstract. The effect of enteral carnitine administration in humans. Zhonghua Nan.Ke.Xue 2012;18(5):428-431. Hamedi-Kalajahi F, Zarezadeh M, Mojtahedi SY, Shabbidar S, Fahimi D, Imani H. Effect of L-carnitine supplementation on lipid profile and apolipoproteins in children on hemodialysis: a randomized placebo-controlled clinical trial. Nagai, N., Kameda, N., Kobashi, R., Nishida, M., Horikawa, C., Egawa, K., Yoshimura, M., Kitagawa, Y., Abe, K., Kiso, Y., Sakane, N., Kotani, K., and Moritani, T. Effect of L-carnitine intake upon reduction of hunger feeling in young healthy females. Clin Ter. Gomez-Amores, L., Mate, A., Miguel-Carrasco, J. L., Jimenez, L., Jos, A., Camean, A. M., Revilla, E., Santa-Maria, C., and Vazquez, C. M. L-carnitine attenuates oxidative stress in hypertensive rats. J Cardiopulm.Rehabil.Prev. Role of L-carnitine in apnea of prematurity: a randomized, controlled trial. [L-carnitine: safe and effective for asthenozoospermia]. [Clinical efficacy of intravenous L-carnitine in patients with right-sided heart failure induced by pulmonary arterial hypertension]. 2013;88(6):544-551. Pehlivanoglu S, Enar R Mutlu H Sert A Ersalni M Yazicioglu N. The effect of L-carnitine on left ventricular function in patients with acute myocardial infarction treated with streptokinase. 1990;5(3):263-265. L-Carnosine (Fig. Clin Drug Investig. View abstract. Yang, L., Yin, H., Yang, R., and Huang, X. Lancet 5-12-1979;1(8124):1041-1042. De Marchi, S., Zecchetto, S., Rigoni, A., Prior, M., Fondrieschi, L., Scuro, A., Rulfo, F., and Arosio, E. Propionyl-L-carnitine improves endothelial function, microcirculation and pain management in critical limb ischemia. Infusionsther.Klin.Ernahr. View abstract. Vacha, G. M., Giorcelli, G., D'Iddio, S., Valentini, G., Bagiella, E., Procopio, A., di Donato, S., Ashbrook, D., and Corsi, M. L-carnitine addition to dialysis fluid. Gibault, J. P., Frey, A., Guiraud, M., Schirardin, H., Bouletreau, P., and Bach, A. C. Effects of L-carnitine infusion on intralipid clearance and utilization. View abstract. 2012;1:CD008427. You may report them to the FDA. Silverio, R., Laviano, A., Rossi, Fanelli F., and Seelaender, M. L-Carnitine induces recovery of liver lipid metabolism in cancer cachexia. Zhou, X., Liu, F., and Zhai, S. Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review. Drugs Exp Clin Res 1999;25:167-71. The use of CAM by women suffering from nausea and vomiting during pregnancy. Casciani, C. U., Caruso, U., Cravotto, E., D'Iddio, S., Corsi, M., Pola, P., Savi, L., and Grilli, M. L-carnitine in haemodialysed patients. It may not be safe to take this supplement if you have liver or kidney disease, high blood pressure, seizure disorder or diabetes. Arch.Gerontol.Geriatr. China Food Additives 2003;5:40-43. Br J Cancer 2002;86:1854-7. Saudi.J Kidney Dis Transpl. Cancer Chemother Pharmacol 1999;44:170-2. Can.J Public Health 2008;99(4):276-280. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's Disease. View abstract. Sabry, A. Yang SK, Xiao L, Song PA, Xu X, Liu FY, Sun L. Effect of L-carnitine therapy on patients in maintenance hemodialysis: a systematic review and meta-analysis. Biol Neonate 1990;58:81-8. Changes in lipid pattern. In one study, 2 grams of acetyl-L-carnitine per day resulted in an almost 10-point drop in systolic blood pressure the top number of a blood pressure reading and an important indicator of heart health and disease risk (23).
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