Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. Chemical Formula: (C6H10O5)n 1.4. We can send by Fedex, by ship or by plane according to international rules. JFIF ` ` ZExif MM * J Q Q Q C Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. gac74 [#B6`Wnw7 l~5C Watch Now. SCMm_>x^O9l (n. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. : 160182 Date Approved: 05/25/2010 Revision No. These grades have particle sizes ranging from <30 to approximately 200. Performing this action will revert the following features to their default settings: Hooray! It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. lH5JWy}DgKRR"Fs Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. CAS #: 9004-34-6 . Heavy metals, % NMT 0.001 More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. Report Category. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. . <> q9;v80q>jZ >> Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. No. CAS 9004-34-6, pH 5 - 7.5. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. Combines good flow and high compactibility. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. EMCOCEL XLM 90. % >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ 2 0 obj Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. Quantity: 1 700 kgs. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. 1.3. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. (&E. Avicel RC-591 & CL-611 - Description. Trademarks: Avicel PH-102. endobj stream Chemical Formula: (C6H10O5)n 1.4. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Truly distinctive drug delivery solutions. stream For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. CoA. Fiber supplements can lessen the absorption of some . MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. Go to Investor Relations. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. In large quantities it provides dietary bulk and may lead to a laxative effect. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. . FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. X\o^ Learn about FMC's differentiated biologically-based crop solutions. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . It is hygroscopic and insoluble in water. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. cas:9032-51-3 msds CELLULOSE PAB. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. <> F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. Molecular weight: Not Applicable 1.5. endobj Find answers in our support articles. A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. Molecular Weight null. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W 2008-2023 ChemPoint. POLYOX resins are nonionic polyethylene oxide solubility polymers. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. ). /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. 4 0 obj There may be more fiber in your food than you realized. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) . Have an order or account question? (1962). bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O We are artists at heart and creators by nature. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. Millipore. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. Protect them from sunshine or rain. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. Microcrystalline Cellulose / Avicel PH-102. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. The table below shows the most common physicochemical parameters of this raw material. EINECS #: 232-674-9 1.7. % PDF (28.38 mb) 2022 Corporate Fact Sheet. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. : CL-611NF Date Approved: 01/13/2010. Wu, K. Zuurman, H.W. Validity Area. 0.25 - 0.37. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Aqueous suspensions of microcrystalline cellulose have . Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. Magazine: Material safety data sheet - FMC Corporation. G2W4de=u183KGH{ vQ#4:1\wc Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Micro Crystalline Cellulose. ChemicalBook. Packaging: 34 x 50 kgs fiber drums. If you are already a ChemPoint customer then sign up for access to our online ordering website. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). % Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. AVICEL RC 581. Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. Van Veen, G.K. Bolhuis, Y.S. q9;v80 Your file is uploaded and ready to be published. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . /MediaBox [0 0 612 792] Document(s): certificate data msds. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P Cellulose microcrystalline for column chromatography. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. 4 0 obj Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. Microcrystalline Cellulose. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. 4 0 obj Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. 4. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. Microcrystalline Cellulose Side Effects. %PDF-1.4 EMCOCEL 90 M. 130. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. Buy Chemicals. Product Name Cellulose microcrystalline. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . It is also used in plaque assays for counting. . 5 0 obj /Contents 4 0 R The figure below illustrates the structural organisation of cellulose within plants. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . The most. stream Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. << Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Origin(s): Plant/Botanical. A., and Smith, P. A. 1.3. 1 0 obj The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. q86@on$^X_HuH;3` << Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. Page 1 of 8. pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ Explore how you can develop your career and bring your creative ideas to life at IFF. Avicel PH-200 microcrystalline cellulose NF, Ph. Earth Supplied Products LLC. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . The cellulose molecule is formed through repeated condensation of cellobiose units. <> The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. PharmaCentral 2021 . Test Data Available. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. B;vLZpHU%ChUyD+[ xv}O2' H~KEe9>G/,:9\i /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) CAS 9004-34-6. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. There have always been two different points of view for the liquidity of MCC. Material safety data sheet - FMC Corporation. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. PDF (4.11 mb) Footer menu 1. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. gwf;J(e0o|1p{R~P^);ao!%{0KD7. 6 \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Revision No. Instead, they obtained a stable colloidal suspension. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge endstream Avicel Microcrystalline Cellulose: Chemical Identifiers. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. Avicel PH-101. It . SDS - Safety Data Sheet. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. : 9004-34-6 Date Approved: 01/31/2008 . GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. ( This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. ( DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. The data shown below apply only to Avicel PH 101. Terms and Conditions Compliance Solutions Industries About 3E News & Events . A family of polysaccharide products that allow distinctive drug delivery solutions. 0.25 - 0.37. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. Looking for FMC'searnings news? Request media, explore upcoming events and read our latest updates. Powder becomes slippery when wet. ( };khd5x=fr pH 6.0 to 8.0 . Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Are you sure you want to delete your template? endobj JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. Safety Data Sheet for Cellulose microcrystalline 102331. 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(AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. Production of Pharmaceutical Grade Microcrystalline Cellulose. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no Learn about FMC's industry leading goal of net-zero emissions by 2035. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . Watch Now. This Microcrystalline Cellulose . << The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. 3 0 obj It is, however, a good source of fibre. MCC helps in the formation of spheres because of its . common form is used in vitamin supplements or tablets. Avicel PC 611 (FMC Biopolymer) Supplied by. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. Date Approved: 05/25/2010. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. 9,LL!z Microcrystalline cellulose -The oldest polymer finds new industrial uses,. Battista, O. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. Explore how we work and why we apply science and creativity for a better world to everything we do. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. 1 0 obj The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . Gloves, eye protection and a dust mask should be used. Remove <> Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. 1 0 obj Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. >> Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. Safety Data Sheet (SDS) Viewer. In extrusion-spheronisation, it is the excipient of choice. All Rights Reserved. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Are you looking for information about products and services by region? Medium size standard MCC grade, suited for the majority of directly compressible actives. Avicel PC 611 (FMC Biopolymer) . However, it yields non-digestible fibre. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. % Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. Product Name: Microcrystalline Cellulose E460 1.2. *r_ *?~4$ &0Y# MATERIAL SAFETY DATA SHEET Version: 1.0 1. Quick Links. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. Microcrystalline cellulose (C6H10O5)n is refined wood pulp. Eur., JPE . {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . Manufactured by: China . ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. Avicel PC 611 Microcrystalline Cellulose. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. FMC Corporation. Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO!
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